Clinical Trials

Study Evaluating Zanidatamab as First-Line Treatment in Advanced/ Metastatic HER2-Positive Gastroesophageal Adenocarcinomas (GEAs)

HERIZON-GEA-01 is a global, randomized, open-label Phase III study to evaluate and compare the efficacy and safety of zanidatamab plus chemotherapy with or without tislelizumab to the standard of care (trastuzumab plus chemotherapy) as first-line treatment for patients with advanced/metastatic human epidermal growth factor receptor 2 (HER2) positive gastroesophageal adenocarcinomas (GEAs). This study is being conducted to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy. Recruitment for the study will occur at approximately 300 trial sites in more than 30 countries, and is designed to have approximately 900 adult patients with HER2-positive gastroesophageal cancer participate. For more information about this study and participating sites, visit clinicaltrials.gov (and search “NCT05152147” or click here), or email clinicaltrialdisclosure@jazzpharma.com.